Narasimha M Beeraka

Cover Letter

I pursued a Bachelors of Pharmacy and a Master of Research (M.Res.) in England in Cell physiology & pharmacology, and PhD in Molecular biology & Pharmacology. 

Research fellow, medical writer and professional content developer expertise: I worked as a medical writer, data analyst at The First Affiliated Hospital of Zhengzhou University and also as a professional content developer in Chegg, USA and India. I used to write clinical trial study designs, and protocols pertinent to ‘cancer research, brain tumors, radiation oncology, radiation physics etc., to help clinicians. As a writer, I have expertise in writing grant proposals to funding bodies. I have been performing statistical analysis of disease markers data related to several diseases. 

Motivation towards research & development: Team work, time management, fertile mind, fast learner, adaptability, hard work and transparency in the data grabbing are my most significant qualities and strengths to work in R & D sector both at academic and Industry levels. 

Research experience:

1. Reviewer: PlosOne, BMC Cancer

2. Published Research articles: 70 

3. Book chapter: 1

4. H-Index: 14

Patents: Oxaliplatin as a blocker of FN3K, a deglycating enzyme of oncogenic Nrf2

Highest Impact Factor published: 17

Research Interests

I (Narasimha M. Beeraka) published several research papers, in Elsevier, Nature, Frontiers, Bentham science, SpringerNature, MDPI, Hindawi etc. My specific interests are based on Bioinformatics, and molecular biology to execute several biomedical research projects pertinent to cancers, neurological/cardiovascular diseases, and biomarker discovery. I am a professional content developer and medical writer. 

• I have expertise in using in silico for artificial intelligence projects through machine learning algorithms, and in vitro, and in vivo using direct and In-direct In situ Hybridization at the light and electron microscopy, DNA, RNA-sequencing dataset analysis, microarrays, Cryo-Electron Microscopy, cell physiology, cell imaging, PCR, ELISA, Western Blotting, Mass spectrometry, NMR, X-ray diffraction, Cell Transfection, qRT-PCR, etc.,

• Skills: Experimental design & execution, manuscript writing, drafting, and publishing, Idea development, and grant proposal writing to funding bodies.

As the epigenetic studies related to the chemoresistance, and tumor proliferation is emerging, the development of the gene-based molecular therapies is one of the significant research arenas to target several cancers which need scientific exploration at both academic and industry level. For instance, the chemoresistance is one of the major obstacles in cancer patients occurring due to the development of stemness factors in proliferating cancer cells which limits effective clinical outcomes in the cancer patients. However, the rate of drug-repurposing has been increasing across the several labs to examine the efficacy of the existing drugs against chemoresistant cancers. However, these studies need substantial research reports on several varieties of cancers. 

In addition, the combinatorial therapeutic implications of existing phytomedicine with chemotherapeutics can mitigate the dose-mediated adverse toxicity in the cancer patients. The underlying mechanisms behind the efficacy of these combination regimen yet to be examined vividly in several cancers. 

Another research arena is the development of immune-oncology based CART- therapies for radioresistant and chemoresistant cancers.     

Furthermore, I am interested in expanding my research to other areas such as neuroscience, immunology, cardiometabolic diseases, genomics, proteomics, and prognostic biomarkers by exploring underlying cell signalling modulations attributed to the disease progression. I have attended and presented several conferences, workshops, and poster presentations at national and international levels. I am interested in enhancing my research skills, and expertise by working in other additional segments of R&Ds both in the industry level, and academic level. 

• I have more than 10 published articles of original and review in the core of neuroscience research & development.
• I have more than 10 published articles of original and review in the core of cardiometabolic disease research & development.
• I have more than 30 published articles of original and review in the core of molecular biology & oncology, disease markers.

Referees:

Prof Ruitai Fan, MD, PhD, Director & Chairman, Cancer Center, Dept. of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, China.

Prof Junqi Liu, MD, PhD, Associate Professor, Cancer Center, Dept. of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, China

Prof Gurupadayya BM, MPharm, PhD, Professor & Head, Dept. of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Shivarathreeshwara Nagar,  India. 

Yours Truly

Dr. Narasimha M Beeraka, B.Pharm., M.Res. (UK), Ph.D. (India)