Microfluidics Technology for IVF

When the male companion is proven to be infertile, the microfluidic sperm sorter procedure comes in handy. Highly mobile, structurally sound, and DNA-intact spermatozoa are extracted from semen using breakthrough technology, and these spermatozoa are then used to fertilize oocytes.

This method is based on a concept known as "Microfluidics" It has been noted that sperms with ideal physiology and genetic makeup have a high degree of forwarding motility. An embryologist makes use of this characteristic of sperm in this procedure. The sperms are essentially engineered to run through a restricted fluid stream. This race is won by the healthiest sperms, who are then gathered in a particular chamber.

To maximize sperm production while minimizing sperm damage and DNA fragmentation, microfluidic technology is used for sperm measurement, quality analysis, and sorting. These sperm are then used in IUI, IVF, or ICSI. When the semen sample has poor semen parameters, it is quite helpful and helps to improve the results.

The best IVF doctors in Hyderabad can execute a variety of IVF treatments and procedures at Esha IVF with a high rate of success. In order to obtain the highest sperm output without endangering the sperms or causing DNA fragmentation, microfluidic technology is employed for sperm quantification, analysis, and sorting. Microfluidics is useful in situations where the characteristics of the semen are insufficient and helps to increase the amount and quality of the semen. They aid in choosing sperm that is healthy, mobile, and of good quality.

Utilizing microfluidic technology for semen analysis

Diagnosis is the first stage of treatment. Low sperm concentration, vitality, motility, and DNA damage can all contribute to male infertility. Current methods like counting chambers, CASA, and SCSA take a lot of time, are challenging, prone to operator mistakes, or need expensive lab equipment. Additionally, they want a semen sample from the male participant, which deters men from complying.

For the examination of sperm, microfluidic chips can replace traditional manual procedures. These screening chips allow for patient screening at home and can be thrown away. Without having to see the doctor in person, patients who are receiving therapy can monitor their progress. The patient's condition can be communicated to the doctor using online software.

The bulk of conventional procedures relies on sample batch analysis. However, because they are adjustable, microfluidic technologies can boost sensitivity and accuracy to single-sperm resolution.

Many of the concepts outlined in the literature could be commercialized with additional research. These microfluidics chips are available to the market for use in point-of-care and clinical settings. 

Microfluidic chips for the selection and sorting of sperm

Two popular assisted reproduction methods are IVF and ICSI. In IVF, a pool of sperm is placed around the egg, whereas in ICSI, only one sperm is injected into the egg. Sperm selection is crucial to both procedures. An essential stage in ARTs is choosing a motile, morphologically healthy sperm. The likelihood of getting pregnant and having a live birth can both rise with the use of healthy, high-quality sperm with strong DNA integrity. A defective and diseased sperm can prevent reproduction or have an impact on the health of the offspring.

The sperm must travel a great distance inside the body before it can reach the egg. The likelihood of sick and injured sperms reaching the egg is decreased by the difficulty of crossing this path. The absence of this natural process in ARTs, however, can have a detrimental impact on both the success rate of the procedure and the health of the progeny. The results of the current sperm selection procedures, such as the density gradient or swim-up approach, depend on the skill of the embryologist and are inefficient.

Microfluidic sperm selection chips enable the creation of more biologically relevant habitats, which leads to the selection of high-quality sperm, overcoming the limitations of conventional techniques in simulating the natural sperm selection process.

The female reproductive system is extremely intricate. In contrast to conventional methods, microfluidic chips and devices can be made to give the sperm a bioinspired habitat, increasing selectivity. The sperm's natural environment is frequently replicated in the microfluidic chips, or they may have microchannels that distinguish healthy, motile sperm from those with defects.

Visit Esha IVF if you have any additional questions about microfluidics or would like more information about any IVF process. We have a watchful and knowledgeable team of experts ready to help you and provide you with the best IVF therapy, including microfluidic in Hyderabad.